rabbit polyclonal anti wave2 antibody (Santa Cruz Biotechnology)
Structured Review

Rabbit Polyclonal Anti Wave2 Antibody, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 89 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rabbit+polyclonal+anti+wave2+antibody/pmc12361339-50-0-7?v=Santa+Cruz+Biotechnology
Average 93 stars, based on 89 article reviews
Images
1) Product Images from "Expression and Regulatory Roles of SKAP2 and Cortactin in Mouse Ovarian Tissue and Oocyte Maturation"
Article Title: Expression and Regulatory Roles of SKAP2 and Cortactin in Mouse Ovarian Tissue and Oocyte Maturation
Journal: Reproductive Sciences
doi: 10.1007/s43032-025-01925-4
Figure Legend Snippet: Immunofluorescence analysis was performed to assess the spatial co-localization of SKAP2 and WAVE2 during oocyte meiotic maturation. As shown in Fig. 8, SKAP2 exhibited predominant localization in the proximal cortical region of oocytes from metaphase I (MI) to metaphase II (MII) stages. Furthermore, SKAP2-WAVE2 co-localization displayed stage-specific patterns: (1) at the MI stage, concentrated asymmetrically at the cell membrane periphery; (2) during anaphase I (AI), distributed along the emergent cell membrane; and (3) at the MII stage, localized specifically at the intercellular junction between daughter cells. All experiments were repeated at least three times
Techniques Used: Immunofluorescence, Membrane
Figure Legend Snippet: To investigate SKAP2-mediated regulation of WAVE2 membrane dynamics, immunofluorescence analysis was performed in control and SKAP2 knockdown oocytes. As shown in Fig. 10, in control groups, WAVE2 exhibited stable expression and cortical localization throughout meiotic progression, with stage-specific co-localization patterns with F-actin: (1) asymmetric cortical clustering at metaphase I (MI), (2) peripheral membrane distribution during anaphase I (AI), and (3) intercellular junction accumulation at metaphase II (MII). However, SKAP2 depletion significantly reduced WAVE2 expression levels and disrupted its co-localization with F-actin across all meiotic stages. All experiments were repeated at least three times. Data are shown as the mean ± standard deviation. The Student’s t-test was used for data analysis. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001
Techniques Used: Membrane, Immunofluorescence, Control, Knockdown, Expressing, Standard Deviation